Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can help to relieve pain and inflammation. Sciatica is a condition that results when the sciatic nerve is compressed or irritated. This can cause pain, numbness, and tingling in the lower back, buttocks, and legs. ibuprofen. [ i-bu´pro-fen] a nonsteroidal antiinflammatory drug used as an analgesic and antipyretic and for symptomatic relief of dysmenorrhea, vascular headaches, rheumatoid arthritis, osteoarthritis, and other rheumatic and nonrheumatic inflammatory disorders. Acetaminophen is an effective mild pain reliever with a low risk of side effects. It carries a risk of liver damage even at recommended dosages, but the risk is increased with higher dosages, a more. Prescription and OTC. Ibuprofen is effective for the short-term relief of minor aches and pains and also reduces inflammation. Ibuprofen Prices, Coupons and Patient Assistance Programs. Ibuprofen is a member of the Nonsteroidal anti-inflammatory drugs drug class and is commonly used for Aseptic Necrosis, Back Pain, Chronic Myofascial Pain, and others. Brand names for ibuprofen include Advil, Motrin IB, Advil Liqui-Gels, and Children's Motrin. No. All OTC ibuprofen is 200 mg. IB sounds fancier, I guess, in the marketing department. There is no sustained release version or enteric coated version of ibuprofen in the US. marketing scam. They don't make the Motrin IB tablets anymore. Mixing ibuprofen and alcohol increases the risk of nephrosclerosis and a condition called acute tubular necrosis, where the tiny ducts within the kidneys begin to collapse due to tissue death. The risk of ibuprofen-induced kidney injury is highest in: Older individuals. People with preexisting kidney disease. Ibuprofen. Ibuprofen is effective for the short-term relief of minor aches and pains and also reduces inflammation. The risk of stomach-related side effects is about half that seen with aspirin although the more. Paracetamol is another name for acetaminophen which is an effective mild pain reliever with a low risk of side effects. Ibuprofen Biological Activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. Ibuprofen inhibits the enzyme cyclooxygenase COX-1 and COX-2, which convert arachidonic acid to prostaglandin H2 (PGH2). Its action is similar to aspirin, indomethacin and all other NSAIDs in intact Aqgn.